This family contains only one protein, SET7/9, which mono-methylates histone at H3K4 92 KMT7 was discovered to methylate, besides histone, legal professional quite a lot of non-histone proteins, including p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear factor kappaB (NFκB), and components of the TATA binding protein (TBP) complex, TBP-associated elements TAF10 and TAF7 ninety three The consensus recognition sequence in substrates for SET7-mediated lysine methylation, Ok/R-S/T-Okay (target lysine is bold), is also acknowledged by the H3K4 demethylase KDM1A/LSD1, which is capable of removing the methyl mark on most of these substrates 17 , 94 Therefore KMT7/KDM1A has emerged as a classic model for dynamic lysine methylation of each histone and non-histone proteins.

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